ChloroquineV1, France, Analysis, bibRecord, 000326

Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.

Identifieur interne : 000326 ( France/Analysis ); précédent : 000325; suivant : 000327

Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.

Auteurs : Apiwat Baramee [France] ; Alexandra Coppin [France] ; Marlène Mortuaire [France] ; Lydie Pelinski [France] ; Stanislas Tomavo [France] ; Jacques Brocard [France]

Source :

Bioorganic and Medicinal Chemistry [ 0968-0896 ] ; 2006.

RBID : Hal:hal-00086276

Abstract

Fourteen ferrocenyl aminohydroxynaphthoquinones, analogues of atovaquone, were synthesized from the hydroxynaphthoquinone core. These novel atovaquone derivatives were tested for their in vitro activity against two apicomplexan parasites of medical importance, Toxoplasma gondii and Plasmodium falciparum, including resistant strains to atovaquone (T. gondii) and chloroquine (P. falciparum). Three of these ferrocenic atovaquone derivatives composed of the hydroxynaphthoquinone core plus an amino-ferrocenic group and an aliphatic chain with 6-8 carbon atoms were found to be significantly active against T. gondii. Moreover, these novel compounds were also effective against the atovaquone-resistant strain of T. gondii (Ato(R)).

Url:

https://hal.archives-ouvertes.fr/hal-00086276

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000226
to stream Hal, to step Curation: 000226
to stream Hal, to step Checkpoint: 000229
to stream Main, to step Merge: 001E14
to stream Main, to step Curation: 001C06
to stream Main, to step Exploration: 001C06
to stream France, to step Extraction: 000326

Links to Exploration step

Hal:hal-00086276

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.</title>
<author><name sortKey="Baramee, Apiwat" sort="Baramee, Apiwat" uniqKey="Baramee A" first="Apiwat" last="Baramee">Apiwat Baramee</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1180" status="VALID">          <orgName>Laboratoire de catalyse de Lille</orgName>
          <orgName type="acronym">LCL</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique Bd Paul Langevin - BP BP 48 59651 VILLENEUVE D ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-92973" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation name="UMR8010" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92973" type="direct"><org type="institution" xml:id="struct-92973" status="OLD">          <idno type="IdRef">026404184</idno>
          <orgName>Université de Lille, Sciences et Technologies</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>Cité Scientifique - 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille1.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8010" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Coppin, Alexandra" sort="Coppin, Alexandra" uniqKey="Coppin A" first="Alexandra" last="Coppin">Alexandra Coppin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mortuaire, Marlene" sort="Mortuaire, Marlene" uniqKey="Mortuaire M" first="Marlène" last="Mortuaire">Marlène Mortuaire</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Pelinski, Lydie" sort="Pelinski, Lydie" uniqKey="Pelinski L" first="Lydie" last="Pelinski">Lydie Pelinski</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1180" status="VALID">          <orgName>Laboratoire de catalyse de Lille</orgName>
          <orgName type="acronym">LCL</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique Bd Paul Langevin - BP BP 48 59651 VILLENEUVE D ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-92973" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation name="UMR8010" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92973" type="direct"><org type="institution" xml:id="struct-92973" status="OLD">          <idno type="IdRef">026404184</idno>
          <orgName>Université de Lille, Sciences et Technologies</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>Cité Scientifique - 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille1.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8010" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Tomavo, Stanislas" sort="Tomavo, Stanislas" uniqKey="Tomavo S" first="Stanislas" last="Tomavo">Stanislas Tomavo</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1180" status="VALID">          <orgName>Laboratoire de catalyse de Lille</orgName>
          <orgName type="acronym">LCL</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique Bd Paul Langevin - BP BP 48 59651 VILLENEUVE D ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-92973" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation name="UMR8010" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92973" type="direct"><org type="institution" xml:id="struct-92973" status="OLD">          <idno type="IdRef">026404184</idno>
          <orgName>Université de Lille, Sciences et Technologies</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>Cité Scientifique - 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille1.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8010" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00086276</idno>
<idno type="halId">hal-00086276</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00086276</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00086276</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Hal/Corpus">000226</idno>
<idno type="wicri:Area/Hal/Curation">000226</idno>
<idno type="wicri:Area/Hal/Checkpoint">000229</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000229</idno>
<idno type="wicri:doubleKey">0968-0896:2006:Baramee A:synthesis:and:in</idno>
<idno type="wicri:Area/Main/Merge">001E14</idno>
<idno type="wicri:Area/Main/Curation">001C06</idno>
<idno type="wicri:Area/Main/Exploration">001C06</idno>
<idno type="wicri:Area/France/Extraction">000326</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.</title>
<author><name sortKey="Baramee, Apiwat" sort="Baramee, Apiwat" uniqKey="Baramee A" first="Apiwat" last="Baramee">Apiwat Baramee</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1180" status="VALID">          <orgName>Laboratoire de catalyse de Lille</orgName>
          <orgName type="acronym">LCL</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique Bd Paul Langevin - BP BP 48 59651 VILLENEUVE D ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-92973" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation name="UMR8010" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92973" type="direct"><org type="institution" xml:id="struct-92973" status="OLD">          <idno type="IdRef">026404184</idno>
          <orgName>Université de Lille, Sciences et Technologies</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>Cité Scientifique - 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille1.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8010" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Coppin, Alexandra" sort="Coppin, Alexandra" uniqKey="Coppin A" first="Alexandra" last="Coppin">Alexandra Coppin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mortuaire, Marlene" sort="Mortuaire, Marlene" uniqKey="Mortuaire M" first="Marlène" last="Mortuaire">Marlène Mortuaire</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Pelinski, Lydie" sort="Pelinski, Lydie" uniqKey="Pelinski L" first="Lydie" last="Pelinski">Lydie Pelinski</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1180" status="VALID">          <orgName>Laboratoire de catalyse de Lille</orgName>
          <orgName type="acronym">LCL</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique Bd Paul Langevin - BP BP 48 59651 VILLENEUVE D ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-92973" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation name="UMR8010" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92973" type="direct"><org type="institution" xml:id="struct-92973" status="OLD">          <idno type="IdRef">026404184</idno>
          <orgName>Université de Lille, Sciences et Technologies</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>Cité Scientifique - 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille1.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8010" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Tomavo, Stanislas" sort="Tomavo, Stanislas" uniqKey="Tomavo S" first="Stanislas" last="Tomavo">Stanislas Tomavo</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1330" status="OLD">          <idno type="IdRef">134442571</idno>
          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ugsf-umr-glycobiologie.univ-lille1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8576" active="#struct-441569" type="direct"></relation>
            <relation name="USC1409" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1180" status="VALID">          <orgName>Laboratoire de catalyse de Lille</orgName>
          <orgName type="acronym">LCL</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique Bd Paul Langevin - BP BP 48 59651 VILLENEUVE D ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-92973" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation name="UMR8010" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92973" type="direct"><org type="institution" xml:id="struct-92973" status="OLD">          <idno type="IdRef">026404184</idno>
          <orgName>Université de Lille, Sciences et Technologies</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>Cité Scientifique - 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille1.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8010" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<series><title level="j">Bioorganic and Medicinal Chemistry</title>
<idno type="ISSN">0968-0896</idno>
<imprint><date type="datePub">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="it"><term>Anti-malaria activity</term>
<term>Atovaquone</term>
<term>Ferrocene</term>
<term>Toxoplasmosis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Fourteen ferrocenyl aminohydroxynaphthoquinones, analogues of atovaquone, were synthesized from the hydroxynaphthoquinone core. These novel atovaquone derivatives were tested for their in vitro activity against two apicomplexan parasites of medical importance, Toxoplasma gondii and Plasmodium falciparum, including resistant strains to atovaquone (T. gondii) and chloroquine (P. falciparum). Three of these ferrocenic atovaquone derivatives composed of the hydroxynaphthoquinone core plus an amino-ferrocenic group and an aliphatic chain with 6-8 carbon atoms were found to be significantly active against T. gondii. Moreover, these novel compounds were also effective against the atovaquone-resistant strain of T. gondii (Ato(R)).</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Baramee, Apiwat" sort="Baramee, Apiwat" uniqKey="Baramee A" first="Apiwat" last="Baramee">Apiwat Baramee</name>
</noRegion>
<name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name>
<name sortKey="Coppin, Alexandra" sort="Coppin, Alexandra" uniqKey="Coppin A" first="Alexandra" last="Coppin">Alexandra Coppin</name>
<name sortKey="Mortuaire, Marlene" sort="Mortuaire, Marlene" uniqKey="Mortuaire M" first="Marlène" last="Mortuaire">Marlène Mortuaire</name>
<name sortKey="Pelinski, Lydie" sort="Pelinski, Lydie" uniqKey="Pelinski L" first="Lydie" last="Pelinski">Lydie Pelinski</name>
<name sortKey="Tomavo, Stanislas" sort="Tomavo, Stanislas" uniqKey="Tomavo S" first="Stanislas" last="Tomavo">Stanislas Tomavo</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000326 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000326 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:hal-00086276
   |texte=   Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.

Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri